ONGene
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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

999

Name

CDH1

Synonym

Arc-1|CD324|CDHE|ECAD|LCAM|UVO;cadherin 1, type 1, E-cadherin (epithelial);CDH1;cadherin 1, type 1, E-cadherin (epithelial)

Definition

CAM 120/80|E-Cadherin|cadherin 1, E-cadherin (epithelial)|cadherin-1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|epithelial cadherin|uvomorulin

Position

16q22.1

Gene Type

protein-coding

Pathways and Diseases

Pathway

Apoptosis;Reactome;REACT:578

Pathway

Cell junction organization;Reactome;REACT:20676

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

Integrin cell surface interactions;PID Reactome;500004

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514

Pathway

tgf beta signaling pathway;PID BioCarta;100017

Pathway

E-cadherin signaling in keratinocytes;PID Curated;200125

Pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032

Pathway

Integrin cell surface interactions;Reactome;REACT:13552

Pathway

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;PID Reactome;500477

Pathway

Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100

Pathway

Adherens junction;KEGG PATHWAY;hsa04520

Pathway

a6b1 and a6b4 Integrin signaling;PID Curated;200162

Pathway

Nectin adhesion pathway;PID Curated;200053

Pathway

Thyroid cancer;KEGG PATHWAY;hsa05216

Pathway

CDC42 signaling events;PID Curated;200057

Pathway

Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130

Pathway

Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106

Pathway

downregulated of mta-3 in er-negative breast tumors;PID BioCarta;100102

Pathway

Wnt signaling pathway;PANTHER;P00057

Pathway

Cadherin signaling pathway;PANTHER;P00012

Pathway

E-cadherin signaling events;PID Curated;200094

Pathway

E-cadherin signaling in the nascent adherens junction;PID Curated;200105

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Alzheimer disease-presenilin pathway;PANTHER;P00004

Pathway

Arf6 trafficking events;PID Curated;200046

Pathway

RAC1 signaling pathway;PID Curated;200190

Pathway

Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155

Pathway

sumoylation as a mechanism to modulate ctbp-dependent gene responses;PID BioCarta;100195

Pathway

Apoptotic cleavage of cell adhesion proteins;PID Reactome;500272

Pathway

FGF signaling pathway;PID Curated;200189

Disease

Thyroid cancer;KEGG DISEASE;H00032

Disease

Gastric cancer;KEGG DISEASE;H00018

Disease

urothelial cancer;GAD

Disease

urinary calculus;GAD

Disease

bladder cancer;GAD

Disease

Breast cancer, lobular;OMIM

Disease

Endometrial carcinoma;OMIM

Disease

Cleft lip with or without cleft palate, with gastric cancer, familial diffuse;OMIM

Disease

IMMUNE;GAD

Disease

transitional cell carcinoma of the bladder.;GAD

Disease

Cancers of endocrine organs;KEGG DISEASE

Disease

prostate cancer;GAD

Disease

METABOLIC;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Ulcerative colitis;NHGRI

Disease

gastric carcinoma risk;GAD

Disease

colorectal cancer;GAD

Disease

Breast cancer;KEGG DISEASE;H00031

Disease

Gastric cancer, familial diffuse;OMIM

Disease

Hepatocellular carcinoma;KEGG DISEASE;H00048

Disease

Crohn Disease;GAD

Disease

Penile cancer;KEGG DISEASE;H00025

Disease

CANCER;GAD

Disease

Colorectal cancer;NHGRI

Disease

Ovarian carcinoma;OMIM

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

Listeria monocytogenes, susceptibility to;OMIM

Disease

Cancers;KEGG DISEASE

Disease

diffuse gastric cancer;GAD

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

Nasopharyngeal cancer;KEGG DISEASE;H00054

Disease

Head and neck cancers;KEGG DISEASE

Disease

ulcerative colitis;GAD

Disease

stomach cancer;GAD

External Links

Links to cell senescence gene database

999

Links to epithelial mesenchymal transition gene database

999

Links to ovarian cancer gene database

999

Links to endometrial cancer gene database

999

Links to iHOP

999

Sequence Information

Nucleotide Sequence

>999 : length: 4969
TTAGGTTGGGCCAACTGAGAATTTTGGGGACTTTCCTTGCTGTGAATGTGGAATTAAATT
GCTTTTTTATTTTTATTTTTTATTTTTCGAGATGGAGTCTCGCTCTGTCGCCAGGTACAG
TGGCGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTTGCCTGCCTC
AGCCTCCTGAGTAGCTGGGACTACAGGCAACTGCCACCACACCTGGCTAATTTTTGTATT
TTTGGTAGAGACAGGGTTTCTCCATGTTGGCCAGGATGGTCTCGATCTCCTGACCTCATG
ATCCGTCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCTGGC
TGCTTTTTAATTTTTTTGGAAAGGTAGGGGGGATTTGGTCAATGATTAATCCATCTGGAG
TTTGGTAACGGATCCAGCAGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTA
TTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCC
TCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAG
AAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCA
TCAGGCCTCCGTTTCTGGAATCCAAGCAGAATTGCTCACATTTCCCAACTCCTCTCCTGG
CCTCAGAAGACAGAAGAGAGACTGGGTTATTCCTCCCATCAGCTGCCCAGAAAATGAAAA
AGGCCCATTTCCTAAAAACCTGGTTCAGATCAAATCCAACAAAGACAAAGAAGGCAAGGT
TTTCTACAGCATCACTGGCCAAGGAGCTGACACACCCCCTGTTGGTGTCTTTATTATTGA
AAGAGAAACAGGATGGCTGAAGGTGACAGAGCCTCTGGATAGAGAACGCATTGCCACATA
CACTCTCTTCTCTCACGCTGTGTCATCCAACGGGAATGCAGTTGAGGATCCAATGGAGAT
TTTGATCACGGTAACCGATCAGAATGACAACAAGCCCGAATTCACCCAGGAGGTCTTTAA
GGGGTCTGTCATGGAAGGTGCTCTTCCAGGAACCTCTGTGATGGAGGTCACAGCCACAGA
CGCGGACGATGATGTGAACACCTACAATGCCGCCATCGCTTACACCATCCTCAGCCAAGA
TCCTGAGCTCCCTGACAAAAATATGTTCACCATTAACAGGAACACAGGAGTCATCAGTGT
GGTCACCACTGGGCTGGACCGAGAGAGTTTCCCTACGTATACCCTGGTGGTTCAAGCTGC
TGACCTTCAAGGTGAGGGGTTAAGCACAACAGCAACAGCTGTGATCACAGTCACTGACAC
CAACGATAATCCTCCGATCTTCAATCCCACCACGTACAAGGGTCAGGTGCCTGAGAACGA
GGCTAACGTCGTAATCACCACACTGAAAGTGACTGATGCTGATGCCCCCAATACCCCAGC
GTGGGAGGCTGTATACACCATATTGAATGATGATGGTGGACAATTTGTCGTCACCACAAA
TCCAGTGAACAACGATGGCATTTTGAAAACAGCAAAGGGCTTGGATTTTGAGGCCAAGCA
GCAGTACATTCTACACGTAGCAGTGACGAATGTGGTACCTTTTGAGGTCTCTCTCACCAC
CTCCACAGCCACCGTCACCGTGGATGTGCTGGATGTGAATGAAGCCCCCATCTTTGTGCC
TCCTGAAAAGAGAGTGGAAGTGTCCGAGGACTTTGGCGTGGGCCAGGAAATCACATCCTA
CACTGCCCAGGAGCCAGACACATTTATGGAACAGAAAATAACATATCGGATTTGGAGAGA
CACTGCCAACTGGCTGGAGATTAATCCGGACACTGGTGCCATTTCCACTCGGGCTGAGCT
GGACAGGGAGGATTTTGAGCACGTGAAGAACAGCACGTACACAGCCCTAATCATAGCTAC
AGACAATGGTTCTCCAGTTGCTACTGGAACAGGGACACTTCTGCTGATCCTGTCTGATGT
GAATGACAACGCCCCCATACCAGAACCTCGAACTATATTCTTCTGTGAGAGGAATCCAAA
GCCTCAGGTCATAAACATCATTGATGCAGACCTTCCTCCCAATACATCTCCCTTCACAGC
AGAACTAACACACGGGGCGAGTGCCAACTGGACCATTCAGTACAACGACCCAACCCAAGA
ATCTATCATTTTGAAGCCAAAGATGGCCTTAGAGGTGGGTGACTACAAAATCAATCTCAA
GCTCATGGATAACCAGAATAAAGACCAAGTGACCACCTTAGAGGTCAGCGTGTGTGACTG
TGAAGGGGCCGCTGGCGTCTGTAGGAAGGCACAGCCTGTCGAAGCAGGATTGCAAATTCC
TGCCATTCTGGGGATTCTTGGAGGAATTCTTGCTTTGCTAATTCTGATTCTGCTGCTCTT
GCTGTTTCTTCGGAGGAGAGCGGTGGTCAAAGAGCCCTTACTGCCCCCAGAGGATGACAC
CCGGGACAACGTTTATTACTATGATGAAGAAGGAGGCGGAGAAGAGGACCAGGACTTTGA
CTTGAGCCAGCTGCACAGGGGCCTGGACGCTCGGCCTGAAGTGACTCGTAACGACGTTGC
ACCAACCCTCATGAGTGTCCCCCGGTATCTTCCCCGCCCTGCCAATCCCGATGAAATTGG
AAATTTTATTGATGAAAATCTGAAAGCGGCTGATACTGACCCCACAGCCCCGCCTTATGA
TTCTCTGCTCGTGTTTGACTATGAAGGAAGCGGTTCCGAAGCTGCTAGTCTGAGCTCCCT
GAACTCCTCAGAGTCAGACAAAGACCAGGACTATGACTACTTGAACGAATGGGGCAATCG
CTTCAAGAAGCTGGCTGACATGTACGGAGGCGGCGAGGACGACTAGGGGACTCGAGAGAG
GCGGGCCCCAGACCCATGTGCTGGGAAATGCAGAAATCACGTTGCTGGTGGTTTTTCAGC
TCCCTTCCCTTGAGATGAGTTTCTGGGGAAAAAAAAGAGACTGGTTAGTGATGCAGTTAG
TATAGCTTTATACTCTCTCCACTTTATAGCTCTAATAAGTTTGTGTTAGAAAAGTTTCGA
CTTATTTCTTAAAGCTTTTTTTTTTTTCCCATCACTCTTTACATGGTGGTGATGTCCAAA
AGATACCCAAATTTTAATATTCCAGAAGAACAACTTTAGCATCAGAAGGTTCACCCAGCA
CCTTGCAGATTTTCTTAAGGAATTTTGTCTCACTTTTAAAAAGAAGGGGAGAAGTCAGCT
ACTCTAGTTCTGTTGTTTTGTGTATATAATTTTTTAAAAAAAATTTGTGTGCTTCTGCTC
ATTACTACACTGGTGTGTCCCTCTGCCTTTTTTTTTTTTTTAAGACAGGGTCTCATTCTA
TCGGCCAGGCTGGAGTGCAGTGGTGCAATCACAGCTCACTGCAGCCTTGTCCTCCCAGGC
TCAAGCTATCCTTGCACCTCAGCCTCCCAAGTAGCTGGGACCACAGGCATGCACCACTAC
GCATGACTAATTTTTTAAATATTTGAGACGGGGTCTCCCTGTGTTACCCAGGCTGGTCTC
AAACTCCTGGGCTCAAGTGATCCTCCCATCTTGGCCTCCCAGAGTATTGGGATTACAGAC
ATGAGCCACTGCACCTGCCCAGCTCCCCAACTCCCTGCCATTTTTTAAGAGACAGTTTCG
CTCCATCGCCCAGGCCTGGGATGCAGTGATGTGATCATAGCTCACTGTAACCTCAAACTC
TGGGGCTCAAGCAGTTCTCCCACCAGCCTCCTTTTTATTTTTTTGTACAGATGGGGTCTT
GCTATGTTGCCCAAGCTGGTCTTAAACTCCTGGCCTCAAGCAATCCTTCTGCCTTGGCCC
CCCAAAGTGCTGGGATTGTGGGCATGAGCTGCTGTGCCCAGCCTCCATGTTTTAATATCA
ACTCTCACTCCTGAATTCAGTTGCTTTGCCCAAGATAGGAGTTCTCTGATGCAGAAATTA
TTGGGCTCTTTTAGGGTAAGAAGTTTGTGTCTTTGTCTGGCCACATCTTGACTAGGTATT
GTCTACTCTGAAGACCTTTAATGGCTTCCCTCTTTCATCTCCTGAGTATGTAACTTGCAA
TGGGCAGCTATCCAGTGACTTGTTCTGAGTAAGTGTGTTCATTAATGTTTATTTAGCTCT
GAAGCAAGAGTGATATACTCCAGGACTTAGAATAGTGCCTAAAGTGCTGCAGCCAAAGAC
AGAGCGGAACTATGAAAAGTGGGCTTGGAGATGGCAGGAGAGCTTGTCATTGAGCCTGGC
AATTTAGCAAACTGATGCTGAGGATGATTGAGGTGGGTCTACCTCATCTCTGAAAATTCT
GGAAGGAATGGAGGAGTCTCAACATGTGTTTCTGACACAAGATCCGTGGTTTGTACTCAA
AGCCCAGAATCCCCAAGTGCCTGCTTTTGATGATGTCTACAGAAAATGCTGGCTGAGCTG
AACACATTTGCCCAATTCCAGGTGTGCACAGAAAACCGAGAATATTCAAAATTCCAAATT
TTTTTCTTAGGAGCAAGAAGAAAATGTGGCCCTAAAGGGGGTTAGTTGAGGGGTAGGGGG
TAGTGAGGATCTTGATTTGGATCTCTTTTTATTTAAATGTGAATTTCAACTTTTGACAAT
CAAAGAAAAGACTTTTGTTGAAATAGCTTTACTGTTTCTCAAGTGTTTTGGAGAAAAAAA
TCAACCCTGCAATCACTTTTTGGAATTGTCTTGATTTTTCGGCAGTTCAAGCTATATCGA
ATATAGTTCTGTGTAGAGAATGTCACTGTAGTTTTGAGTGTATACATGTGTGGGTGCTGA
TAATTGTGTATTTTCTTTGGGGGTGGAAAAGGAAAACAATTCAAGCTGAGAAAAGTATTC
TCAAAGATGCATTTTTATAAATTTTATTAAACAATTTTGTTAAACCATT

Protein Sequence

>999 : length: 882
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDC
TGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVG
HHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS
NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGN
AVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAI
AYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT
AVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDG
GQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDV
NEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTG
AISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTI
FFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEV
GDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILAL
LILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARP
EVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGS
EAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD