ONGene
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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

7298

Name

TYMS

Synonym

HST422|TMS|TS;thymidylate synthetase;TYMS;thymidylate synthetase

Definition

TSase|thymidylate synthase

Position

18p11.32

Gene Type

protein-coding

Pathways and Diseases

Pathway

E2F transcription factor network;PID Curated;200027

Pathway

Formyltetrahydroformate biosynthesis;PANTHER;P02743

Pathway

De novo pyrimidine deoxyribonucleotide biosynthesis;PANTHER;P02739

Pathway

pyrimidine deoxyribonucleotides de novo biosynthesis;BioCyc;PWY0-166

Pathway

One carbon pool by folate;KEGG PATHWAY;hsa00670

Pathway

Metabolic pathways;KEGG PATHWAY;hsa01100

Pathway

Pyrimidine metabolism;KEGG PATHWAY;hsa00240

Pathway

Cell Cycle, Mitotic;Reactome;REACT:152

Pathway

Tetrahydrofolate biosynthesis;PANTHER;P02742

Pathway

Metabolism of nucleotides;Reactome;REACT:1698

Disease

Central nervous system disease;FunDO

Disease

Cytomegalovirus infection;FunDO

Disease

Cancer;FunDO

Disease

DEVELOPMENTAL;GAD

Disease

neural tube defects;GAD

Disease

lung cancer;GAD

Disease

PHARMACOGENOMIC;GAD

Disease

Rheumatoid arthritis;FunDO

Disease

head and neck cancer;GAD

Disease

METABOLIC;GAD

Disease

colorectal cancer;GAD

Disease

folate;GAD

Disease

esophageal cancer;GAD

Disease

Thrombophlebitis;FunDO

Disease

CANCER;GAD

Disease

Hypertension;FunDO

Disease

leukemia;GAD

Disease

Abortion;FunDO

Disease

methotrexate toxicity;GAD

Disease

stomach cancer;GAD

Disease

homocystinuria;GAD

Disease

Folic acid deficiency;FunDO

External Links

Links to cell senescence gene database

7298

Links to epithelial mesenchymal transition gene database

7298

Links to ovarian cancer gene database

7298

Links to endometrial cancer gene database

7298

Links to iHOP

7298

Sequence Information

Nucleotide Sequence

>7298 : length: 1603
CGGGACGGCCGCGGGAAAAGGCGCGCGGAAGGGGTCCTGCCACCGCGCCACTTGGCCTGC
CTCCGTCCCGCCGCGCCACTTGGCCTGCCTCCGTCCCGCCGCGCCACTTCGCCTGCCTCC
GTCCCCCGCCCGCCGCGCCATGCCTGTGGCCGGCTCGGAGCTGCCGCGCCGGCCCTTGCC
CCCCGCCGCACAGGAGCGGGACGCCGAGCCGCGTCCGCCGCACGGGGAGCTGCAGTACCT
GGGGCAGATCCAACACATCCTCCGCTGCGGCGTCAGGAAGGACGACCGCACGGGCACCGG
CACCCTGTCGGTATTCGGCATGCAGGCGCGCTACAGCCTGAGAGATGAATTCCCTCTGCT
GACAACCAAACGTGTGTTCTGGAAGGGTGTTTTGGAGGAGTTGCTGTGGTTTATCAAGGG
ATCCACAAATGCTAAAGAGCTGTCTTCCAAGGGAGTGAAAATCTGGGATGCCAATGGATC
CCGAGACTTTTTGGACAGCCTGGGATTCTCCACCAGAGAAGAAGGGGACTTGGGCCCAGT
TTATGGCTTCCAGTGGAGGCATTTTGGGGCAGAATACAGAGATATGGAATCAGATTATTC
AGGACAGGGAGTTGACCAACTGCAAAGAGTGATTGACACCATCAAAACCAACCCTGACGA
CAGAAGAATCATCATGTGCGCTTGGAATCCAAGAGATCTTCCTCTGATGGCGCTGCCTCC
ATGCCATGCCCTCTGCCAGTTCTATGTGGTGAACAGTGAGCTGTCCTGCCAGCTGTACCA
GAGATCGGGAGACATGGGCCTCGGTGTGCCTTTCAACATCGCCAGCTACGCCCTGCTCAC
GTACATGATTGCGCACATCACGGGCCTGAAGCCAGGTGACTTTATACACACTTTGGGAGA
TGCACATATTTACCTGAATCACATCGAGCCACTGAAAATTCAGCTTCAGCGAGAACCCAG
ACCTTTCCCAAAGCTCAGGATTCTTCGAAAAGTTGAGAAAATTGATGACTTCAAAGCTGA
AGACTTTCAGATTGAAGGGTACAATCCGCATCCAACTATTAAAATGGAAATGGCTGTTTA
GGGTGCTTTCAAAGGAGCTCGAAGGATATTGTCAGTCTTTAGGGGTTGGGCTGGATGCCG
AGGTAAAAGTTCTTTTTGCTCTAAAAGAAAAAGGAACTAGGTCAAAAATCTGTCCGTGAC
CTATCAGTTATTAATTTTTAAGGATGTTGCCACTGGCAAATGTAACTGTGCCAGTTCTTT
CCATAATAAAAGGCTTTGAGTTAACTCACTGAGGGTATCTGACAATGCTGAGGTTATGAA
CAAAGTGAGGAGAATGAAATGTATGTGCTCTTAGCAAAAACATGTATGTGCATTTCAATC
CCACGTACTTATAAAGAAGGTTGGTGAATTTCACAAGCTATTTTTGGAATATTTTTAGAA
TATTTTAAGAATTTCACAAGCTATTCCCTCAAATCTGAGGGAGCTGAGTAACACCATCGA
TCATGATGTAGAGTGTGGTTATGAACTTTAAAGTTATAGTTGTTTTATATGTTGCTATAA
TAAAGAAGTGTTCTGCATTCGTCAAAAAAAAAAAAAAAAAAAA

Protein Sequence

>7298 : length: 313
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV