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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

6774

Name

STAT3

Synonym

ADMIO|APRF|HIES;signal transducer and activator of transcription 3 (acute-phase response factor);STAT3;signal transducer and activator of transcription 3 (acute-phase response factor)

Definition

DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3

Position

17q21.31

Gene Type

protein-coding

Pathways and Diseases

Pathway

Signaling events mediated by TCPTP;PID Curated;200065

Pathway

Signaling events mediated by HDAC Class I;PID Curated;200070

Pathway

role of erbb2 in signal transduction and oncology;PID BioCarta;100147

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

ErbB1 downstream signaling;PID Curated;200113

Pathway

IL23-mediated signaling events;PID Curated;200131

Pathway

CXCR4-mediated signaling events;PID Curated;200083

Pathway

pdgf signaling pathway;PID BioCarta;100077

Pathway

IL12 signaling mediated by STAT4;PID Curated;200197

Pathway

IL12-mediated signaling events;PID Curated;200034

Pathway

Toxoplasmosis;KEGG PATHWAY;hsa05145

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

Signaling by PDGF;Reactome;REACT:16888

Pathway

IL27-mediated signaling events;PID Curated;200023

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

egf signaling pathway;PID BioCarta;100181

Pathway

EGF receptor (ErbB1) signaling pathway;PID Curated;200085

Pathway

Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128

Pathway

PDGFR-beta signaling pathway;PID Curated;200127

Pathway

EGF receptor signaling pathway;PANTHER;P00018

Pathway

IL2-mediated signaling events;PID Curated;200082

Pathway

Notch-mediated HES/HEY network;PID Curated;200196

Pathway

Ras Pathway;PANTHER;P04393

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

IFN-gamma pathway;PID Curated;200110

Pathway

Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920

Pathway

ErbB2/ErbB3 signaling events;PID Curated;200119

Pathway

bioactive peptide induced signaling pathway;PID BioCarta;100226

Pathway

Signaling events mediated by PTP1B;PID Curated;200033

Pathway

JAK/STAT signaling pathway;PANTHER;P00038

Pathway

Angiogenesis;PANTHER;P00005

Pathway

erk1/erk2 mapk signaling pathway;PID BioCarta;100170

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630

Pathway

tpo signaling pathway;PID BioCarta;100012

Pathway

il22 soluble receptor signaling pathway;PID BioCarta;100131

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

il 6 signaling pathway;PID BioCarta;100126

Pathway

IL6-mediated signaling events;PID Curated;200124

Pathway

RAC1 signaling pathway;PID Curated;200190

Pathway

Interleukin signaling pathway;PANTHER;P00036

Pathway

Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156

Pathway

stat3 signaling pathway;PID BioCarta;100028

Pathway

GMCSF-mediated signaling events;PID Curated;200015

Pathway

Acute myeloid leukemia;KEGG PATHWAY;hsa05221

Disease

Cancers;KEGG DISEASE

Disease

Other well-defined immunodeficiency syndromes;KEGG DISEASE;H00107

Disease

Multiple sclerosis;NHGRI

Disease

multiple sclerosis;GAD

Disease

IMMUNE;GAD

Disease

Immune system diseases;KEGG DISEASE

Disease

Hyper-IgE recurrent infection syndrome;OMIM

Disease

kidney cancer;GAD

Disease

PHARMACOGENOMIC;GAD

Disease

Oral cancer;KEGG DISEASE;H00016

Disease

Asthma;GAD

Disease

Crohn's disease;GAD

Disease

Head and neck cancers;KEGG DISEASE

Disease

Crohn's disease;NHGRI

Disease

Primary immunodeficiency;KEGG DISEASE

External Links

Links to cell senescence gene database

6774

Links to epithelial mesenchymal transition gene database

6774

Links to ovarian cancer gene database

6774

Links to endometrial cancer gene database

6774

Links to iHOP

6774

Sequence Information

Nucleotide Sequence

>6774 : length: 4978
GGTTTCCGGAGCTGCGGCGGCGCAGACTGGGAGGGGGAGCCGGGGGTTCCGACGTCGCAG
CCGAGGGAACAAGCCCCAACCGGATCCTGGACAGGCACCCCGGCTTGGCGCTGTCTCTCC
CCCTCGGCTCGGAGAGGCCCTTCGGCCTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACG
CGCAGCCCCGGCCTCTCGGCCTCTGCCGGAGAAACAGTTGGGACCCCTGATTTTAGCAGG
ATGGCCCAATGGAATCAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAG
CTCTACAGTGACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGT
CAAGATTGGGCATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTC
CTGGGAGAGATTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAG
CACAATCTACGAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAG
ATTGCCCGGATTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCC
ACTGCGGCCCAGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAG
CAGCAGATGCTGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAG
AAAATGAAAGTGGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAG
AGTCAAGGAGACATGCAAGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATG
CAGCAGCTGGAACAGATGCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAG
CTGGCGGGGCTTTTGTCAGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTG
GCTGACTGGAAGAGGCGGCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTA
GATCGGCTAGAAAACTGGATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAA
ATTAAGAAACTGGAGGAGTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAG
CACCGGCCGATGCTGGAGGAGAGAATCGTGGAGCTGTTTAGAAACTTAATGAAAAGTGCC
TTTGTGGTGGAGCGGCAGCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAG
ACCGGCGTCCAGTTCACTACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTAT
CAGCTTAAAATTAAAGTGTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGA
TCCCGGAAATTTAACATTCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAAC
AACGGCAGCCTCTCTGCAGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAAT
GGGGGCCGAGCCAATTGTGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACC
TTTGAGACCGAGGTGTATCACCAAGGCCTCAAGATTGACCTAGAGACCCACTCCTTGCCA
GTTGTGGTGATCTCCAACATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTAC
AACATGCTGACCAACAATCCCAAGAATGTAAACTTTTTTACCAAGCCCCCAATTGGAACC
TGGGATCAAGTGGCCGAGGTCCTGAGCTGGCAGTTCTCCTCCACCACCAAGCGAGGACTG
AGCATCGAGCAGCTGACTACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCA
GGGTGTCAGATCACATGGGCTAAATTTTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCC
TTCTGGGTCTGGCTGGACAATATCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGG
AACGAAGGGTACATCATGGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACT
AAGCCTCCAGGCACCTTCCTGCTAAGATTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACT
TTCACTTGGGTGGAGAAGGACATCAGCGGTAAGACCCAGATCCAGTCCGTGGAACCATAC
ACAAAGCAGCAGCTGAACAACATGTCATTTGCTGAAATCATCATGGGCTATAAGATCATG
GATGCTACCAATATCCTGGTGTCTCCACTGGTCTATCTCTATCCTGACATTCCCAAGGAG
GAGGCATTCGGAAAGTATTGTCGGCCAGAGAGCCAGGAGCATCCTGAAGCTGACCCAGGT
AGCGCTGCCCCATACCTGAAGACCAAGTTTATCTGTGTGACACCAACGACCTGCAGCAAT
ACCATTGACCTGCCGATGTCCCCCCGCACTTTAGATTCATTGATGCAGTTTGGAAATAAT
GGTGAAGGTGCTGAACCCTCAGCAGGAGGGCAGTTTGAGTCCCTCACCTTTGACATGGAG
TTGACCTCGGAGTGCGCTACCTCCCCCATGTGAGGAGCTGAGAACGGAAGCTGCAGAAAG
ATACGACTGAGGCGCCTACCTGCATTCTGCCACCCCTCACACAGCCAAACCCCAGATCAT
CTGAAACTACTAACTTTGTGGTTCCAGATTTTTTTTAATCTCCTACTTCTGCTATCTTTG
AGCAATCTGGGCACTTTTAAAAATAGAGAAATGAGTGAATGTGGGTGATCTGCTTTTATC
TAAATGCAAATAAGGATGTGTTCTCTGAGACCCATGATCAGGGGATGTGGCGGGGGGTGG
CTAGAGGGAGAAAAAGGAAATGTCTTGTGTTGTTTTGTTCCCCTGCCCTCCTTTCTCAGC
AGCTTTTTGTTATTGTTGTTGTTGTTCTTAGACAAGTGCCTCCTGGTGCCTGCGGCATCC
TTCTGCCTGTTTCTGTAAGCAAATGCCACAGGCCACCTATAGCTACATACTCCTGGCATT
GCACTTTTTAACCTTGCTGACATCCAAATAGAAGATAGGACTATCTAAGCCCTAGGTTTC
TTTTTAAATTAAGAAATAATAACAATTAAAGGGCAAAAAACACTGTATCAGCATAGCCTT
TCTGTATTTAAGAAACTTAAGCAGCCGGGCATGGTGGCTCACGCCTGTAATCCCAGCACT
TTGGGAGGCCGAGGCGGATCATAAGGTCAGGAGATCAAGACCATCCTGGCTAACACGGTG
AAACCCCGTCTCTACTAAAAGTACAAAAAATTAGCTGGGTGTGGTGGTGGGCGCCTGTAG
TCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGAGAGGCGGAGGTTGC
AGTGAGCCAAAATTGCACCACTGCACACTGCACTCCATCCTGGGCGACAGTCTGAGACTC
TGTCTCAAAAAAAAAAAAAAAAAAAAGAAACTTCAGTTAACAGCCTCCTTGGTGCTTTAA
GCATTCAGCTTCCTTCAGGCTGGTAATTTATATAATCCCTGAAACGGGCTTCAGGTCAAA
CCCTTAAGACATCTGAAGCTGCAACCTGGCCTTTGGTGTTGAAATAGGAAGGTTTAAGGA
GAATCTAAGCATTTTAGACTTTTTTTTATAAATAGACTTATTTTCCTTTGTAATGTATTG
GCCTTTTAGTGAGTAAGGCTGGGCAGAGGGTGCTTACAACCTTGACTCCCTTTCTCCCTG
GACTTGATCTGCTGTTTCAGAGGCTAGGTTGTTTCTGTGGGTGCCTTATCAGGGCTGGGA
TACTTCTGATTCTGGCTTCCTTCCTGCCCCACCCTCCCGACCCCAGTCCCCCTGATCCTG
CTAGAGGCATGTCTCCTTGCGTGTCTAAAGGTCCCTCATCCTGTTTGTTTTAGGAATCCT
GGTCTCAGGACCTCATGGAAGAAGAGGGGGAGAGAGTTACAGGTTGGACATGATGCACAC
TATGGGGCCCCAGCGACGTGTCTGGTTGAGCTCAGGGAATATGGTTCTTAGCCAGTTTCT
TGGTGATATCCAGTGGCACTTGTAATGGCGTCTTCATTCAGTTCATGCAGGGCAAAGGCT
TACTGATAAACTTGAGTCTGCCCTCGTATGAGGGTGTATACCTGGCCTCCCTCTGAGGCT
GGTGACTCCTCCCTGCTGGGGCCCCACAGGTGAGGCAGAACAGCTAGAGGGCCTCCCCGC
CTGCCCGCCTTGGCTGGCTAGCTCGCCTCTCCTGTGCGTATGGGAACACCTAGCACGTGC
TGGATGGGCTGCCTCTGACTCAGAGGCATGGCCGGATTTGGCAACTCAAAACCACCTTGC
CTCAGCTGATCAGAGTTTCTGTGGAATTCTGTTTGTTAAATCAAATTAGCTGGTCTCTGA
ATTAAGGGGGAGACGACCTTCTCTAAGATGAACAGGGTTCGCCCCAGTCCTCCTGCCTGG
AGACAGTTGATGTGTCATGCAGAGCTCTTACTTCTCCAGCAACACTCTTCAGTACATAAT
AAGCTTAACTGATAAACAGAATATTTAGAAAGGTGAGACTTGGGCTTACCATTGGGTTTA
AATCATAGGGACCTAGGGCGAGGGTTCAGGGCTTCTCTGGAGCAGATATTGTCAAGTTCA
TGGCCTTAGGTAGCATGTATCTGGTCTTAACTCTGATTGTAGCAAAAGTTCTGAGAGGAG
CTGAGCCCTGTTGTGGCCCATTAAAGAACAGGGTCCTCAGGCCCTGCCCGCTTCCTGTCC
ACTGCCCCCTCCCCATCCCCAGCCCAGCCGAGGGAATCCCGTGGGTTGCTTACCTACCTA
TAAGGTGGTTTATAAGCTGCTGTCCTGGCCACTGCATTCAAATTCCAATGTGTACTTCAT
AGTGTAAAAATTTATATTATTGTGAGGTTTTTTGTCTTTTTTTTTTTTTTTTTTTTTTGG
TATATTGCTGTATCTACTTTAACTTCCAGAAATAAACGTTATATAGGAACCGTAAAAA

Protein Sequence

>6774 : length: 770
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM