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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

4193

Name

MDM2

Synonym

ACTFS|HDMX|hdm2;MDM2 proto-oncogene, E3 ubiquitin protein ligase;MDM2;MDM2 proto-oncogene, E3 ubiquitin protein ligase

Definition

E3 ubiquitin-protein ligase Mdm2|MDM2 oncogene, E3 ubiquitin protein ligase|Mdm2, p53 E3 ubiquitin protein ligase homolog|Mdm2, transformed 3T3 cell double minute 2, p53 binding protein|double minute 2, human homolog of; p53-binding protein|oncoprotein Md

Position

12q14.3-q15

Gene Type

protein-coding

Pathways and Diseases

Pathway

Endocytosis;KEGG PATHWAY;hsa04144

Pathway

Sumoylation by RanBP2 regulates transcriptional repression;PID Curated;200097

Pathway

Glucocorticoid receptor regulatory network;PID Curated;200077

Pathway

Regulation of retinoblastoma protein;PID Curated;200191

Pathway

Ubiquitin proteasome pathway;PANTHER;P00060

Pathway

Direct p53 effectors;PID Curated;200101

Pathway

hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144

Pathway

cell cycle: g2/m checkpoint;PID BioCarta;100159

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120

Pathway

P53 pathway feedback loops 1;PANTHER;P04392

Pathway

tumor suppressor arf inhibits ribosomal biogenesis;PID BioCarta;100237

Pathway

atm signaling pathway;PID BioCarta;100235

Pathway

ctcf: first multivalent nuclear factor;PID BioCarta;100194

Pathway

p53 pathway;PANTHER;P00059

Pathway

ErbB4 signaling events;PID Curated;200009

Pathway

hypoxia and p53 in the cardiovascular system;PID BioCarta;100084

Pathway

Regulation of Androgen receptor activity;PID Curated;200102

Pathway

p53 signaling pathway;PID BioCarta;100083

Pathway

Trafficking of AMPA receptors;PID Reactome;500171

Pathway

Stabilization of p53;PID Reactome;500316

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

Synaptic Transmission;Reactome;REACT:13685

Pathway

Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033

Pathway

Aurora A signaling;PID Curated;200166

Pathway

Cell cycle;KEGG PATHWAY;hsa04110

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

sumoylation by ranbp2 regulates transcriptional repression;PID BioCarta;100053

Pathway

AKT phosphorylates targets in the cytosol;PID Reactome;500640

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Cell Cycle Checkpoints;Reactome;REACT:1538

Pathway

p53 pathway;PID Curated;200175

Pathway

p53 pathway feedback loops 2;PANTHER;P04398

Pathway

p53 signaling pathway;KEGG PATHWAY;hsa04115

Disease

liver cancer;GAD

Disease

Endometrial Neoplasms;GAD

Disease

Bladder cancer;FunDO

Disease

breast cancer;GAD

Disease

Hepatitis C;FunDO

Disease

Cancer;FunDO

Disease

bladder cancer;GAD

Disease

Eating disorder;FunDO

Disease

Helicobacter Infections;GAD

Disease

Herpes;FunDO

Disease

Alveolar rhabdomyosarcoma;KEGG DISEASE;H00037

Disease

Accelerated tumor formation, susceptibility to;OMIM

Disease

Osteosarcoma;KEGG DISEASE;H00036

Disease

lung cancer;GAD

Disease

Breast Neoplasms;GAD

Disease

Rheumatoid arthritis;FunDO

Disease

DNA Damage;GAD

Disease

Choriocarcinoma;KEGG DISEASE;H00028

Disease

Cirrhosis;FunDO

Disease

Epilepsy;FunDO

Disease

pregnancy loss;GAD

Disease

nasopharyngeal cancer;GAD

Disease

Lung Neoplasms;GAD

Disease

Adenovirus infection;FunDO

Disease

Penile cancer;KEGG DISEASE;H00025

Disease

CANCER;GAD

Disease

Leukemia, Lymphocytic, Chronic, B-Cell;GAD

Disease

Osteosarcoma;GAD

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

Endometriosis;FunDO

Disease

Schistosomiasis;FunDO

Disease

Cancers of the nervous system;KEGG DISEASE

Disease

Stomach Neoplasms;GAD

Disease

REPRODUCTION;GAD

Disease

Cancers;KEGG DISEASE

Disease

Glioma;KEGG DISEASE;H00042

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

Cancers of soft tissues and bone;KEGG DISEASE

Disease

endometrial cancer;GAD

Disease

colorectal cancer;GAD

Disease

stomach cancer;GAD

External Links

Links to cell senescence gene database

4193

Links to epithelial mesenchymal transition gene database

4193

Links to ovarian cancer gene database

4193

Links to endometrial cancer gene database

4193

Links to iHOP

4193

Sequence Information

Nucleotide Sequence

>4193 : length: 7495
GTAGGGGGCGCGCACCGAGGCACCGCGGCGAGCTTGGCTGCTTCTGGGGCCTGTGTGGCC
CTGTGTGTCGGAAAGATGGAGCAAGAAGCCGAGCCCGAGGGGCGGCCGCGACCCCTCTGA
CCGAGATCCTGCTGCTTTCGCAGCCAGGAGCACCGTCCCTCCCCGGATTAGTGCGTACGA
GCGCCCAGTGCCCTGGCCCGGAGAGTGGAATGATCCCCGAGGCCCAGGGCGTCGTGCTTC
CGCGCGCCCCGTGAAGGAAACTGGGGAGTCTTGAGGGACCCCCGACTCCAAGCGCGAAAA
CCCCGGATGGTGAGGAGCAGGCAAATGTGCAATACCAACATGTCTGTACCTACTGATGGT
GCTGTAACCACCTCACAGATTCCAGCTTCGGAACAAGAGACCCTGGTTAGACCAAAGCCA
TTGCTTTTGAAGTTATTAAAGTCTGTTGGTGCACAAAAAGACACTTATACTATGAAAGAG
GTTCTTTTTTATCTTGGCCAGTATATTATGACTAAACGATTATATGATGAGAAGCAACAA
CATATTGTATATTGTTCAAATGATCTTCTAGGAGATTTGTTTGGCGTGCCAAGCTTCTCT
GTGAAAGAGCACAGGAAAATATATACCATGATCTACAGGAACTTGGTAGTAGTCAATCAG
CAGGAATCATCGGACTCAGGTACATCTGTGAGTGAGAACAGGTGTCACCTTGAAGGTGGG
AGTGATCAAAAGGACCTTGTACAAGAGCTTCAGGAAGAGAAACCTTCATCTTCACATTTG
GTTTCTAGACCATCTACCTCATCTAGAAGGAGAGCAATTAGTGAGACAGAAGAAAATTCA
GATGAATTATCTGGTGAACGACAAAGAAAACGCCACAAATCTGATAGTATTTCCCTTTCC
TTTGATGAAAGCCTGGCTCTGTGTGTAATAAGGGAGATATGTTGTGAAAGAAGCAGTAGC
AGTGAATCTACAGGGACGCCATCGAATCCGGATCTTGATGCTGGTGTAAGTGAACATTCA
GGTGATTGGTTGGATCAGGATTCAGTTTCAGATCAGTTTAGTGTAGAATTTGAAGTTGAA
TCTCTCGACTCAGAAGATTATAGCCTTAGTGAAGAAGGACAAGAACTCTCAGATGAAGAT
GATGAGGTATATCAAGTTACTGTGTATCAGGCAGGGGAGAGTGATACAGATTCATTTGAA
GAAGATCCTGAAATTTCCTTAGCTGACTATTGGAAATGCACTTCATGCAATGAAATGAAT
CCCCCCCTTCCATCACATTGCAACAGATGTTGGGCCCTTCGTGAGAATTGGCTTCCTGAA
GATAAAGGGAAAGATAAAGGGGAAATCTCTGAGAAAGCCAAACTGGAAAACTCAACACAA
GCTGAAGAGGGCTTTGATGTTCCTGATTGTAAAAAAACTATAGTGAATGATTCCAGAGAG
TCATGTGTTGAGGAAAATGATGATAAAATTACACAAGCTTCACAATCACAAGAAAGTGAA
GACTATTCTCAGCCATCAACTTCTAGTAGCATTATTTATAGCAGCCAAGAAGATGTGAAA
GAGTTTGAAAGGGAAGAAACCCAAGACAAAGAAGAGAGTGTGGAATCTAGTTTGCCCCTT
AATGCCATTGAACCTTGTGTGATTTGTCAAGGTCGACCTAAAAATGGTTGCATTGTCCAT
GGCAAAACAGGACATCTTATGGCCTGCTTTACATGTGCAAAGAAGCTAAAGAAAAGGAAT
AAGCCCTGCCCAGTATGTAGACAACCAATTCAAATGATTGTGCTAACTTATTTCCCCTAG
TTGACCTGTCTATAAGAGAATTATATATTTCTAACTATATAACCCTAGGAATTTAGACAA
CCTGAAATTTATTCACATATATCAAAGTGAGAAAATGCCTCAATTCACATAGATTTCTTC
TCTTTAGTATAATTGACCTACTTTGGTAGTGGAATAGTGAATACTTACTATAATTTGACT
TGAATATGTAGCTCATCCTTTACACCAACTCCTAATTTTAAATAATTTCTACTCTGTCTT
AAATGAGAAGTACTTGGTTTTTTTTTTTCTTAAATATGTATATGACATTTAAATGTAACT
TATTATTTTTTTTGAGACCGAGTCTTGCTCTGTTACCCAGGCTGGAGTGCAGTGGCGTGA
TCTTGGCTCACTGCAAGCTCTGCCTCCCGGGTTCGCACCATTCTCCTGCCTCAGCCTCCC
AATTAGCTTGGCCTACAGTCATCTGCCACCACACCTGGCTAATTTTTTGTACTTTTAGTA
GAGACAGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCC
CACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGTCCGGCCTAAATG
TCACTTAGTACCTTTGATATAAAGAGAAAATGTGTGAAAGATTTAGTTTTTTGTTTTTTT
GTTTGTTTGTTTGTTTGTTTGTTTTGAGATGAGTCTCTCTGTCGCCCAGGCTGGAGTGCA
GTGTCATGATCTAGCAGTCTCCGCTTCCCGGGTTCAAGCCATTCTCCTGGCTCAGCCTCT
GGAGCAGCTGGGATTACAGGCATGCACCACCATGCCCAGCTAATTTTTGTATTTTTAGTA
GAGATAGGGTTTCACCATGTTGGCCAGGCTGGTCACGAACTCCTGACCTCAAGTGAGGTC
ACCCGCCTCGGCCTCCCGAAGTGCTGGGATTGCAGATGTGAGCCACCATGTCCAGCCAAG
AATTAGTATTTAAATTTTAGATACTCTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAG
AGTCTTGCTCCATCACCCATGCTAGAGTGCAGTGGAGTGATCTCGGCTCACTGCAACTTC
CGCCTTCTGGGTTCAAGCTATTCTCCTGCCTCAGCCTTCCAAGTAACTGGGATTACAGGC
ATGTACCACCATACCAGCTGATTTTTTTGTATTTTTAGTAAAGACAGGGTTTCACCATGT
TAGCCAGGCTGATCTTGAACTCCTAAACTCAAGTGATCTACTCACCTCAGCCTCCCAAAA
TGCTGGGATTACAGATGTGAGGCACCTGGCCTCAGATTTTTGATACTCTTAAACCTTCTG
ATCCTTAGTTTCTCTCTCCAAAATACTCTTTCTAGGTTAAAAAAAAAAAGGCTCTTATAT
TTGGTGCTATGTAAATGAAAATGTTTTTTAGGTTTTCTTGATTTAACAATAGAGACAGGG
TCTCCCTGTGTTGCCCAGGCTGGTCTCGAACTCCTGGGCTCAAGAGATCCTCCTGTCTTG
GCCTCGCAAAGTGCTAAGTAGGATTACAGGCGTTAGCCACCACACCCGGCTGTAAAAATG
TACTTATTCTCCAGCCTCTTTTGTATAAACCATAGTAAGGGATGGGAGTAATGATGTTAT
CTGTGAAAATAGCCACCATTTACCCGTAAGACAAAACTTGTTAAAGCCTCCTGAGTCTAA
CCTAGATTACATCAGGCCCTTTTTCACACACAAAAAAATCCTTTATGGGATTTAATGGAA
TCTGTTGTTTCCCCCTAAGTTGAAAAACAACTCTAAGACACTTTAAAGTACCTTCTTGGC
CTGGGTTACATGGTTCCCAGCCTAGGTTTCAGACTTTTGCTTAAGGCCAGTTTTAGAAAC
CCGTGAATTCAGAAAAGTTAATTCAGAAATTTGATAAACAGAATTGTTATTTAAAAACTA
ACTGGAAAGATTGTTAAGTTCTTTCTGAATTATTCAGAAATTATGCATCATTTTCCTTCA
AGAATGACAGGGTCAGCATGTGGAATTCCAAGATACCTCTTGACTTCCTCTCAAGCTCCG
TGTTTGGTCAGTGGAGGCCCATCCGAGCTCAGCACTGAGAAGTGTTAGTTTCTTTGGGAC
CCATCTACCCTGACCACATCATGATGTTCATCTGCAGCTGTTGCAAGGTGTTCAGATTGT
ATAAACATAAATGTCACAAAAACTTTAAAAGAAGTGCAATTCTCAAAAGGTTAGGTGGAC
TAAAGCATTCTGTAAAGCAACTGCTAATAATGAGCTTACAGTGGATTTGAATTTGAAAAA
TATAGTAACAAGCCTGTCAAATATCTGCAAGAACTATGGAATAAAACTACTGATGCAGTG
AAGACAGTTGAAAAGATCAAACAAATGCCAAGCTATATTTATAATGAACAAATTCAAGAA
AAAGGACTACGGAAAGTTCAGGACATCAAAGAAGTCAGGCAAAACTCATCTTGACCCCTG
TTGCAGGCAAAGGAACGCAGCTGGAAGAAAAGATGATATAACAGTTAACAGGATGCAGAC
ATGGCAGAGGTTTCCTAAAAATCTCATTATCTATAACCATTTCTATATTTACATTTGAAA
ATCTCCTTTGGAGACTTAGAACCTCTAAATTATTGACTTATTTTTTATATAAGGTCACTC
CGATGAAAGGTGATTACAAAATCATCTACATTGCTGTCTACAAAACAGATAATATGGATG
TTTGATCGCATCTCATTGTTAACTCTTTACTGATATGTTTGTAAATACAGAAGTGAAATG
TGGACATAAAATAGTTACGCTATTTGGTTAATGGTACTAGACAACATGTAATTAATGACA
TTCAAAAATTTATGGCTAGTGATATATATAAAGTAAAATTTTCTTTGCAGTAAAATATGC
CCTTTATTATAGAAGGGAGGATATAAGGAACCAACAGTTTGTATGAAAATAGCTCAAATA
ATATCTTTTATTTTGATTTTAATATTTCTTATTTTGGTTTATTAGTGTCTTAGAACAAAA
TGGCCTTATATAATGAAGCCTAGTTATGCTGGACTGTTTTGATCTCTTTTAATTGTTCTG
ACAGATAGTTGGGGATGAGAGCCGAATAAGGTTTGCCTGAAATAACTGACACTATATAAT
TTCTGCTTTGGCAAATACTAAGTTCTAACTTGTCATTCCTGGTAGAACAAGCTTTATTTT
TCGAGCCTAGCAATGATCTAGAAGCAGATGTTATCTCAGTGCCTTTTGCAATTTGTTGTG
TGGGTTTTTTTTTTTTTAAAGCCACACAATAATTTTGGAAAACAATGTATGGGTAGAACA
TGTGTCTGTTAATTGCACACAAAACCACTTTTAATGGGTACAGAGTTAAATTTGAAGGAA
TAAGTTCTAGCTGAAGTATTATGAACTCCAAATAATGCTTTGAGGACCTCCAAAGGTAAA
AGTACTAATCCCTTTGGCCATTTATTGAGAGAGAGAGAGAGAGAGAGTAGGGTGACTATA
GTTAATGTATTGAATGTTCTTGCTACAAATAAATGATATTTGAGCTGATGGGTGTGCTAA
TTACACTGATTTGATCAATACCCATTGTATGTGAAACAGTACATACACCATATTTACAAT
TATGTATTTAACATTTAAAATTTCTAATATAAGTATCTCTCAAACTGTGGATTAACTTCT
TGATTTATATTTAAATATGAATCTTAAGCAAAACAGTGAAAATAACCATCTTGATTTAGT
GTTTTTCTCCCATATGTGAATTGTATATACTTAGGTGAAGACAATAAAATCAACTGAACT
GTAAGCTTAGAATAGGACTGAGGTAATTCTGCACAGCAACTTTACTAATGGTACATTGTT
GCTTCAAAACTCTCTCTCTCTCTCTCTGTCTGTCTCAATAAATGGCCAAAGGGATTAGTA
GTTTACCTGTGGAGGTCCTCCAAGCATTATTTGGAGTTGATAATACTTCAGCTACAACCA
AGCAGAATCTCTTTTTTTTGGAGGTCCTCGAAGCATTATTTGGAGTTGATAATACTTCAG
CTTCAATTTGGAGTTGATAATATTTCAGCTAGAACCTAGTAGAATCTGTTTTTTTCCTTT
GGAGGTCCTCAAAGCATTATTGGAGTTCATAATACTGAAGCTAGAACCAAGCAGAATCTG
TTTTTTTCTGAGGAGTATCGGTAGCATAAATGTGATTATAAACATAGTACACTTGATATA
TGGAGGCAGTGACAGCTATTTTTACAAAATTTAAATCTGCAAATGGATTCAACATGTTTA
TGGGTTATTAAAATTGTCTGATTTCTTAGGTTCTTTATAGTACACGTGTTGAAAATAAAT
GATTAAGAATTGTTTCAAGAATGCAATTATTTGATCTTAAATTTTTATGAGTTGTTAAAA
TAGAAATTATTTGAATATCATATATTTGGGTAACAAAAGGCACAAGTCTGAATGTGTTTC
TTTTTCTGGAATGGCCATGCCTGCCCACTTTAGAAATACAAATATCACTGGGCAGCTTGA
AGCAGTTGGGAGCCTCCAATGAGAGCAACTTGAGAGAATGATGTTGCAAGTTAGTAGGAG
TAAGAAATGCTGTGTTCTCCCTGTCTTCTCTTAGGTCACATGGCAGCCTGGCCTAAGTGA
TCGTGAATGGTCTATAAGGGAGGTAGCTGGGACAGGGAGGGGAGTTTGGGCTAGCCACCG
TACCACTTGTCAGCGTGAAAAGTAAGATTGTAATTGCCTGTTTAGTTTTCTGCCTCATCT
TTGAAAGTTCCACCAAGCTGGGAACCTCTTGATTGTGAGGCACAAATGTAAGTACATCAG
AAAAAAACAAAAAAACTGGCTTTAAAGCAGGAGCTTGTGGGCCCCTAAGCCAGACGGGGA
CTAGCTTTTGGCATTATATAATTAAGATTTTTTAAATCCTTAATAAGGGTTTTATTTTAT
TTTTATTTATTTTTTGAGACGGAGTCTTGCTCTGTGGCTCAGGCTGGAGTACAGTGGTGC
AATCTTGGCTCACTGCAACCTCTGCCTCCTGGCTGTGTTCAAGTGGTTCTGCTTCAGCCT
CCCAAGTAGCTGGGGTTAGAGCACCCTGTCACCACGCCCCGCTAATTTTTGTATTTCTAG
CAGAGATGAAGTTTCACTATGTTGGCCAGGCTGGGCTCAAACTCCTGACCTCAAGTGATC
TGCCCGCCTTGGCCCCCCAAAGTGCTGTGATTACAGGCGTGAGCCGCCACGCCCAGCCTA
ATAAGGGTTTTAAAGATAATTAGTGTGTAGGTCTGTAGGCTTATGATGGTAACCACAAGT
TGTTAATGGCATTGTGAAAAGTTTTTAGTTGCGCTTTATGGGTGGATGCTGAATTACATT
TTGATTTGATACTTATAAAAAGAAAAAGTATTTCTTCAGCTTAAAAAATTGTTTAAAAGT
TTGTGATCATATTGTCTACCATGTAGCCAGCTTTCAATTATATGTAAGAGGGACTTTTTG
ACATTTACAAATAATACTTTGAGGTAGATATCTGAAAGCACCAGCACTTGGAAGGTGTTC
AGAAGTAACAAATTATAAAATGAGCTAACAAACGAAAGGCAAAATAAAACCGTAAAGCAA
GCAGATGGGAGGCGTGTTCAGTAACTTATTCATAATGCATCTGAAATGATTGCTGTACTC
AAATATTTAACGTTAGAGTAATAGTATTTTGAATGAAAACCATAGTTGATTGTCT

Protein Sequence

>4193 : length: 497
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL
FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE
SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDE
LSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEED
PEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAE
EGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEF
EREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKP
CPVCRQPIQMIVLTYFP