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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

3717

Name

JAK2

Synonym

JTK10|THCYT3;Janus kinase 2;JAK2;Janus kinase 2

Definition

JAK-2|Janus kinase 2 (a protein tyrosine kinase)|tyrosine-protein kinase JAK2

Position

9p24

Gene Type

protein-coding

Pathways and Diseases

Pathway

S1P3 pathway;PID Curated;200035

Pathway

ifn gamma signaling pathway;PID BioCarta;100138

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

Interferon-gamma signaling pathway;PANTHER;P00035

Pathway

CXCR4-mediated signaling events;PID Curated;200083

Pathway

IL12-mediated signaling events;PID Curated;200034

Pathway

Toxoplasmosis;KEGG PATHWAY;hsa05145

Pathway

IL4-mediated signaling events;PID Curated;200018

Pathway

il 3 signaling pathway;PID BioCarta;100128

Pathway

EPO signaling pathway;PID Curated;200157

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

growth hormone signaling pathway;PID BioCarta;100155

Pathway

epo signaling pathway;PID BioCarta;100175

Pathway

Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031

Pathway

PI3 kinase pathway;PANTHER;P00048

Pathway

IFN-gamma pathway;PID Curated;200110

Pathway

inhibition of cellular proliferation by gleevec;PID BioCarta;100154

Pathway

Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920

Pathway

ErbB2/ErbB3 signaling events;PID Curated;200119

Pathway

bioactive peptide induced signaling pathway;PID BioCarta;100226

Pathway

no2-dependent il-12 pathway in nk cells;PID BioCarta;100093

Pathway

Signaling events mediated by PTP1B;PID Curated;200033

Pathway

Endothelins;PID Curated;200004

Pathway

JAK/STAT signaling pathway;PANTHER;P00038

Pathway

Notch-mediated HES/HEY network;PID Curated;200196

Pathway

il12 and stat4 dependent signaling pathway in th1 development;PID BioCarta;100133

Pathway

erythropoietin mediated neuroprotection through nf-kb;PID BioCarta;100176

Pathway

Paxillin-independent events mediated by a4b1 and a4b7;PID Curated;200178

Pathway

Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630

Pathway

tpo signaling pathway;PID BioCarta;100012

Pathway

IL23-mediated signaling events;PID Curated;200131

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

IL6-mediated signaling events;PID Curated;200124

Pathway

ErbB4 signaling events;PID Curated;200009

Pathway

IL27-mediated signaling events;PID Curated;200023

Pathway

Leishmaniasis;KEGG PATHWAY;hsa05140

Pathway

Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156

Pathway

GMCSF-mediated signaling events;PID Curated;200015

Pathway

chaperones modulate interferon signaling pathway;PID BioCarta;100016

Disease

myeloproliferative neoplasms;GAD

Disease

leukemia, myeloid;GAD

Disease

HEMATOLOGICAL;GAD

Disease

Leukemia, Myelomonocytic, Chronic;GAD

Disease

Combined immunodeficiency;FunDO

Disease

Cancer;FunDO

Disease

Leukemia, Myeloid, Acute;GAD

Disease

Down syndrome;FunDO

Disease

Myeloproliferative neoplasms;NHGRI

Disease

Myelofibrosis, idiopathic;OMIM

Disease

Choriocarcinoma;FunDO

Disease

Thrombocythemia, essential;OMIM

Disease

IMMUNE;GAD

Disease

Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE

Disease

Rheumatoid arthritis;FunDO

Disease

Budd-Chiari syndrome hematology indices polycythemia vera;GAD

Disease

Polycythemia vera;KEGG DISEASE;H00012

Disease

Ulcerative colitis;NHGRI

Disease

Stroke;FunDO

Disease

Hematologic Neoplasms;GAD

Disease

thrombocythemia;GAD

Disease

Primary biliary cirrhosis;FunDO

Disease

ulcerative colitis;GAD

Disease

myelofibrosis;GAD

Disease

CARDIOVASCULAR;GAD

Disease

CANCER;GAD

Disease

myelofibrosis myeloproliferative disorder polycythemia vera thrombocythemia;GAD

Disease

Crohn's disease;GAD

Disease

Polycythemia;FunDO

Disease

Crohn's disease;NHGRI

Disease

Budd-Chiari syndrome;OMIM

Disease

Cancers;KEGG DISEASE

Disease

Myeloproliferative disease;FunDO

Disease

Primary Myelofibrosis;GAD

Disease

Abortion;FunDO

Disease

Polycythemia vera;OMIM

Disease

Translocation, Genetic;GAD

Disease

Myeloproliferative disorder with erythrocytosis;OMIM

Disease

thromboembolism, venous;GAD

Disease

Hematopoietic system disease;FunDO

Disease

Thrombophilia;FunDO

Disease

Leukemia, acute myelogenous;OMIM

Disease

Atherosclerosis;FunDO

External Links

Links to cell senescence gene database

3717

Links to epithelial mesenchymal transition gene database

3717

Links to ovarian cancer gene database

3717

Links to endometrial cancer gene database

3717

Links to iHOP

3717

Sequence Information

Nucleotide Sequence

>3717 : length: 5285
CTGCAGGAAGGAGAGAGGAAGAGGAGCAGAAGGGGGCAGCAGCGGACGCCGCTAACGGCC
TCCCTCGGCGCTGACAGGCTGGGCCGGCGCCCGGCTCGCTTGGGTGTTCGCGTCGCCACT
TCGGCTTCTCGGCCGGTCGGGCCCCTCGGCCCGGGCTTGCGGCGCGCGTCGGGGCTGAGG
GCTGCTGCGGCGCAGGGAGAGGCCTGGTCCTCGCTGCCGAGGGATGTGAGTGGGAGCTGA
GCCCACACTGGAGGGCCCCCGAGGGCCCAGCCTGGAGGTCGTTCAGAGCCGTGCCCGTCC
CGGGGCTTCGCAGACCTTGACCCGCCGGGTAGGAGCCGCCCCTGCGGGCTCGAGGGCGCG
CTCTGGTCGCCCGATCTGTGTAGCCGGTTTCAGAAGCAGGCAACAGGAACAAGATGTGAA
CTGTTTCTCTTCTGCAGAAAAAGAGGCTCTTCCTCCTCCTCCCGCGACGGCAAATGTTCT
GAAAAAGACTCTGCATGGGAATGGCCTGCCTTACGATGACAGAAATGGAGGGAACATCCA
CCTCTTCTATATATCAGAATGGTGATATTTCTGGAAATGCCAATTCTATGAAGCAAATAG
ATCCAGTTCTTCAGGTGTATCTTTACCATTCCCTTGGGAAATCTGAGGCAGATTATCTGA
CCTTTCCATCTGGGGAGTATGTTGCAGAAGAAATCTGTATTGCTGCTTCTAAAGCTTGTG
GTATCACACCTGTGTATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGT
ATCCACCCAACCATGTCTTCCATATAGATGAGTCAACCAGGCATAATGTACTCTACAGAA
TAAGATTTTACTTTCCTCGTTGGTATTGCAGTGGCAGCAACAGAGCCTATCGGCATGGAA
TATCTCGAGGTGCTGAAGCTCCTCTTCTTGATGACTTTGTCATGTCTTACCTCTTTGCTC
AGTGGCGGCATGATTTTGTGCACGGATGGATAAAAGTACCTGTGACTCATGAAACACAGG
AAGAATGTCTTGGGATGGCAGTGTTAGATATGATGAGAATAGCCAAAGAAAACGATCAAA
CCCCACTGGCCATCTATAACTCTATCAGCTACAAGACATTCTTACCAAAATGTATTCGAG
CAAAGATCCAAGACTATCATATTTTGACAAGGAAGCGAATAAGGTACAGATTTCGCAGAT
TTATTCAGCAATTCAGCCAATGCAAAGCCACTGCCAGAAACTTGAAACTTAAGTATCTTA
TAAATCTGGAAACTCTGCAGTCTGCCTTCTACACAGAGAAATTTGAAGTAAAAGAACCTG
GAAGTGGTCCTTCAGGTGAGGAGATTTTTGCAACCATTATAATAACTGGAAACGGTGGAA
TTCAGTGGTCAAGAGGGAAACATAAAGAAAGTGAGACACTGACAGAACAGGATTTACAGT
TATATTGCGATTTTCCTAATATTATTGATGTCAGTATTAAGCAAGCAAACCAAGAGGGTT
CAAATGAAAGCCGAGTTGTAACTATCCATAAGCAAGATGGTAAAAATCTGGAAATTGAAC
TTAGCTCATTAAGGGAAGCTTTGTCTTTCGTGTCATTAATTGATGGATATTATAGATTAA
CTGCAGATGCACATCATTACCTCTGTAAAGAAGTAGCACCTCCAGCCGTGCTTGAAAATA
TACAAAGCAACTGTCATGGCCCAATTTCGATGGATTTTGCCATTAGTAAACTGAAGAAAG
CAGGTAATCAGACTGGACTGTATGTACTTCGATGCAGTCCTAAGGACTTTAATAAATATT
TTTTGACTTTTGCTGTCGAGCGAGAAAATGTCATTGAATATAAACACTGTTTGATTACAA
AAAATGAGAATGAAGAGTACAACCTCAGTGGGACAAAGAAGAACTTCAGCAGTCTTAAAG
ATCTTTTGAATTGTTACCAGATGGAAACTGTTCGCTCAGACAATATAATTTTCCAGTTTA
CTAAATGCTGTCCCCCAAAGCCAAAAGATAAATCAAACCTTCTAGTCTTCAGAACGAATG
GTGTTTCTGATGTACCAACCTCACCAACATTACAGAGGCCTACTCATATGAACCAAATGG
TGTTTCACAAAATCAGAAATGAAGATTTGATATTTAATGAAAGCCTTGGCCAAGGCACTT
TTACAAAGATTTTTAAAGGCGTACGAAGAGAAGTAGGAGACTACGGTCAACTGCATGAAA
CAGAAGTTCTTTTAAAAGTTCTGGATAAAGCACACAGAAACTATTCAGAGTCTTTCTTTG
AAGCAGCAAGTATGATGAGCAAGCTTTCTCACAAGCATTTGGTTTTAAATTATGGAGTAT
GTGTCTGTGGAGACGAGAATATTCTGGTTCAGGAGTTTGTAAAATTTGGATCACTAGATA
CATATCTGAAAAAGAATAAAAATTGTATAAATATATTATGGAAACTTGAAGTTGCTAAAC
AGTTGGCATGGGCCATGCATTTTCTAGAAGAAAACACCCTTATTCATGGGAATGTATGTG
CCAAAAATATTCTGCTTATCAGAGAAGAAGACAGGAAGACAGGAAATCCTCCTTTCATCA
AACTTAGTGATCCTGGCATTAGTATTACAGTTTTGCCAAAGGACATTCTTCAGGAGAGAA
TACCATGGGTACCACCTGAATGCATTGAAAATCCTAAAAATTTAAATTTGGCAACAGACA
AATGGAGTTTTGGTACCACTTTGTGGGAAATCTGCAGTGGAGGAGATAAACCTCTAAGTG
CTCTGGATTCTCAAAGAAAGCTACAATTTTATGAAGATAGGCATCAGCTTCCTGCACCAA
AGTGGGCAGAATTAGCAAACCTTATAAATAATTGTATGGATTATGAACCAGATTTCAGGC
CTTCTTTCAGAGCCATCATACGAGATCTTAACAGTTTGTTTACTCCAGATTATGAACTAT
TAACAGAAAATGACATGTTACCAAATATGAGGATAGGTGCCCTGGGGTTTTCTGGTGCCT
TTGAAGACCGGGATCCTACACAGTTTGAAGAGAGACATTTGAAATTTCTACAGCAACTTG
GCAAGGGTAATTTTGGGAGTGTGGAGATGTGCCGGTATGACCCTCTACAGGACAACACTG
GGGAGGTGGTCGCTGTAAAAAAGCTTCAGCATAGTACTGAAGAGCACCTAAGAGACTTTG
AAAGGGAAATTGAAATCCTGAAATCCCTACAGCATGACAACATTGTAAAGTACAAGGGAG
TGTGCTACAGTGCTGGTCGGCGTAATCTAAAATTAATTATGGAATATTTACCATATGGAA
GTTTACGAGACTATCTTCAAAAACATAAAGAACGGATAGATCACATAAAACTTCTGCAGT
ACACATCTCAGATATGCAAGGGTATGGAGTATCTTGGTACAAAAAGGTATATCCACAGGG
ATCTGGCAACGAGAAATATATTGGTGGAGAACGAGAACAGAGTTAAAATTGGAGATTTTG
GGTTAACCAAAGTCTTGCCACAAGACAAAGAATACTATAAAGTAAAAGAACCTGGTGAAA
GTCCCATATTCTGGTATGCTCCAGAATCACTGACAGAGAGCAAGTTTTCTGTGGCCTCAG
ATGTTTGGAGCTTTGGAGTGGTTCTGTATGAACTTTTCACATACATTGAGAAGAGTAAAA
GTCCACCAGCGGAATTTATGCGTATGATTGGCAATGACAAACAAGGACAGATGATCGTGT
TCCATTTGATAGAACTTTTGAAGAATAATGGAAGATTACCAAGACCAGATGGATGCCCAG
ATGAGATCTATATGATCATGACAGAATGCTGGAACAATAATGTAAATCAACGCCCCTCCT
TTAGGGATCTAGCTCTTCGAGTGGATCAAATAAGGGATAACATGGCTGGATGAAAGAAAT
GACCTTCATTCTGAGACCAAAGTAGATTTACAGAACAAAGTTTTATATTTCACATTGCTG
TGGACTATTATTACATATATCATTATTATATAAATCATGATGCTAGCCAGCAAAGATGTG
AAAATATCTGCTCAAAACTTTCAAAGTTTAGTAAGTTTTTCTTCATGAGGCCACCAGTAA
AAGACATTAATGAGAATTCCTTAGCAAGGATTTTGTAAGAAGTTTCTTAAACATTGTCAG
TTAACATCACTCTTGTCTGGCAAAAGAAAAAAAATAGACTTTTTCAACTCAGCTTTTTGA
GACCTGAAAAAATTATTATGTAAATTTTGCAATGTTAAAGATGCACAGAATATGTATGTA
TAGTTTTTACCACAGTGGATGTATAATACCTTGGCATCTTGTGTGATGTTTTACACACAT
GAGGGCTGGTGTTCATTAATACTGTTTTCTAATTTTTCCATAGTTAATCTATAATTAATT
ACTTCACTATACAAACAAATTAAGATGTTCAGATAATTGAATAAGTACCTTTGTGTCCTT
GTTCATTTATATCGCTGGCCAGCATTATAAGCAGGTGTATACTTTTAGCTTGTAGTTCCA
TGTACTGTAAATATTTTTCACATAAAGGGAACAAATGTCTAGTTTTATTTGTATAGGAAA
TTTCCCTGACCCTAAATAATACATTTTGAAATGAAACAAGCTTACAAAGATATAATCTAT
TTTATTATGGTTTCCCTTGTATCTATTTGTGGTGAATGTGTTTTTTAAATGGAACTATCT
CCAAATTTTTCTAAGACTACTATGAACAGTTTTCTTTTAAAATTTTGAGATTAAGAATGC
CAGGAATATTGTCATCCTTTGAGCTGCTGACTGCCAATAACATTCTTCGATCTCTGGGAT
TTATGCTCATGAACTAAATTTAAGCTTAAGCCATAAAATAGATTAGATTGTTTTTTAAAA
ATGGATAGCTCATTAAGAAGTGCAGCAGGTTAAGAATTTTTTCCTAAAGACTGTATATTT
GAGGGGTTTCAGAATTTTGCATTGCAGTCATAGAAGAGATTTATTTCCTTTTTAGAGGGG
AAATGAGGTAAATAAGTAAAAAAGTATGCTTGTTAATTTTATTCAAGAATGCCAGTAGAA
AATTCATAACGTGTATCTTTAAGAAAAATGAGCATACATCTTAAATCTTTTCAATTAAGT
ATAAGGGGTTGTTCGTTGTTGTCATTTGTTATAGTGCTACTCCACTTTAGACACCATAGC
TAAAATAAAATATGGTGGGTTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
TGTTATTTATACAAAACTTAAAATACTTGCTGTTTTGATTAAAAAGAAAATAGTTTCTTA
CTTTA

Protein Sequence

>3717 : length: 1132
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG