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Gene information | Literature | Expression | lncRNA | Mutation | Homolog

Basic Information

Gene ID

1398

Name

CRK

Synonym

CRKII|p38;v-crk avian sarcoma virus CT10 oncogene homolog;CRK;v-crk avian sarcoma virus CT10 oncogene homolog

Definition

adapter molecule crk|proto-oncogene c-Crk

Position

17p13.3

Gene Type

protein-coding

Pathways and Diseases

Pathway

ARMS-mediated activation;PID Reactome;500631

Pathway

Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666

Pathway

Signaling events regulated by Ret tyrosine kinase;PID Curated;200058

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

Signaling by Insulin receptor;Reactome;REACT:498

Pathway

Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

E-cadherin signaling in the nascent adherens junction;PID Curated;200105

Pathway

CXCR4-mediated signaling events;PID Curated;200083

Pathway

VEGFR3 signaling in lymphatic endothelium;PID Curated;200188

Pathway

PDGFR-alpha signaling pathway;PID Curated;200140

Pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032

Pathway

IGF1 pathway;PID Curated;200084

Pathway

p130Cas linkage to MAPK signaling for integrins;PID Reactome;500007

Pathway

Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100

Pathway

Signaling by PDGF;Reactome;REACT:16888

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

EPHB forward signaling;PID Curated;200041

Pathway

Integrin cell surface interactions;Reactome;REACT:13552

Pathway

Nectin adhesion pathway;PID Curated;200053

Pathway

Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128

Pathway

Shigellosis;KEGG PATHWAY;hsa05131

Pathway

Signalling by NGF;Reactome;REACT:11061

Pathway

Signaling events mediated by focal adhesion kinase;PID Curated;200192

Pathway

LPA receptor mediated events;PID Curated;200011

Pathway

Insulin signaling pathway;KEGG PATHWAY;hsa04910

Pathway

Insulin Pathway;PID Curated;200012

Pathway

Endothelins;PID Curated;200004

Pathway

ErbB signaling pathway;KEGG PATHWAY;hsa04012

Pathway

JNK signaling in the CD4+ TCR pathway;PID Curated;200129

Pathway

Angiogenesis;PANTHER;P00005

Pathway

Integrin signalling pathway;PANTHER;P00034

Pathway

EPHA forward signaling;PID Curated;200121

Pathway

Paxillin-independent events mediated by a4b1 and a4b7;PID Curated;200178

Pathway

Renal cell carcinoma;KEGG PATHWAY;hsa05211

Pathway

Signaling events mediated by PTP1B;PID Curated;200033

Pathway

Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066

Pathway

Hemostasis;Reactome;REACT:604

Pathway

Signaling in Immune system;Reactome;REACT:6900

Pathway

Chemokine signaling pathway;KEGG PATHWAY;hsa04062

Pathway

Signal attenuation;PID Reactome;500505

Pathway

RAC1 signaling pathway;PID Curated;200190

Pathway

Paxillin-dependent events mediated by a4b1;PID Curated;200117

Disease

Gastritis;FunDO

Disease

Cancer;FunDO

Disease

Influenza;FunDO

External Links

Links to cell senescence gene database

1398

Links to epithelial mesenchymal transition gene database

1398

Links to ovarian cancer gene database

1398

Links to endometrial cancer gene database

1398

Links to iHOP

1398

Sequence Information

Nucleotide Sequence

>1398 : length: 3225
ATTTCCGGAGGGGGAGGCCCGCGGCTGCCGCCGCCATTTCGGGCGCTGCTGTGAAGCTGA
AACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCG
GCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGG
AGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGC
GTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCG
GTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGGTGAGCCCCTCCAGACTCCGAATAGGA
GATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGGAC
ACTACAACGTTGATAGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGG
CAGGAGGAGGCGGAGTATGTGCGAGCCCTCTTTGACTTTAATGGGAATGATGAGGAAGAT
CTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAGCAGTGGTGG
AATGCGGAGGACAGCGAAGGCAAGAGAGGGATGATTCCAGTCCCTTACGTCGAGAAGTAT
AGACCTGCCTCCGCCTCAGTATCGGCTCTGATTGGAGGTAACCAGGAGGGTTCCCACCCA
CAGCCACTGGGTGGGCCGGAGCCTGGGCCCTATGCCCAACCCAGCGTCAACACTCCGCTC
CCTAACCTCCAGAATGGGCCCATATATGCCAGGGTTATCCAGAAGCGAGTCCCCAATGCC
TACGACAAGACAGCCTTGGCTTTGGAGGTCGGTGAGCTGGTAAAGGTTACGAAGATTAAT
GTGAGTGGTCAGTGGGAAGGGGAGTGTAATGGCAAACGAGGTCACTTCCCATTCACACAT
GTCCGTCTGCTGGATCAACAGAATCCCGATGAGGACTTCAGCTGAGTATAGTTCAACAGT
TTTGCTGACAGATGGGAACAATCTTTTTTTTTTTTTTCCAACTGCCATCTATACAATTTT
CTTACAGATGTCAAAAGCAGTCTAGTTTATATAAGCATTCTGTTACCTGTGATATTTTTT
AGACTGAACTGCTCCATTCCTAGTCTTAATTACCATATTCAGGGTACGAACTGGAGGGCT
TGTGTGTTAGCTTCTGAATTGGCAATTGGAGGCGGTAGTGGTCGTGCCTGTGTGTATCAG
AAGGGATAGGTATCTTGCCTCCTTTCTCTCAGGCAGTGCAAATCACCCTGTGGAAAACCG
ATGGACAGGAAGGAGTGTTACACACTGCTTACCCTGATTTATTCAGTGGTTTTGTTTTCA
TTCTGGAACCATACTATCAAATGGCGACAGACTGTTCCGTTCCACCCCCGTGAAGTAATC
ATGCACCGTGTGAATAGTATCAAGCAGGATTGCTTTCATTGTATGGAGCATGACCAGCGT
GTGACTCATTCTGACATTTCAGATCCTAAGAATTCTAAGAACACTACTAGAAGCATTTGT
TCCCTCCTAGTCAATGCTTCATACTTTTTCTTGGGATTCTTTTAGCCCTTGACATTCTTG
TCCCCCAAACCTGTAAGTAGGTGAATTCCTAAGATAAGTGTGTATTTTCATTCCAGGTGA
AAAGCAGGATGTACCGAGCACTTTATTCAGTGCATAGCTTTAAGCCAGTGTTGGATTCAC
TAAGTGGACAGCCAGTCTCCCAGCTCTCTGCCTTCCCCAAAAGGGTCGTAGTAGGTCACC
CTTCTACAGCAGCTAACTAGAGTCCTAACTAATGGGATCCAGCAGGGCCATTTCTCCAGA
GGGCCAGTATCCTATTAGGAGACTCTTGGAATTCTTAGGTTCTACTCAAGAGTGGAAGGA
CCAATCACCTCTGATATTCTGTGGAAGGTTTTGGGGTCAAATTCTGCCCTCTGCATTCTG
TGCAACTTGTATAAAAGTCAAGTTAGTATTACATGAATTTGGGGTAGGGTTAGTGCTTTG
AAAAAATGTTGAACCGGCTGGGCGCGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAG
GCCGAGGCGGGTGGATCATGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAA
CCCCATCTCTGCTAAAGATATAAAAAATTAGCCCGGCGTGGTGGTGCACGCCTGTAATCC
CAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTCAACCTGGGAGGTGGAGGCTGCAGT
GAGCCGAGATCGCACCACTGCGTTCCAGCCTGAGCGACAGGGCAAGACTCAGTCTCAAAA
AAAAAAAAAAGGAAAAAAAAAAGAAAAAAAAATGTTGAACCAATTGTGAATTACTTATGT
ATTATTCATTTCTCATGGGGAGAGTAATGCTGTTGAAGAACATTACATTGTAAACTGCCT
TCATTTTTGGCTCTTTGTTTATGTTCAGGTTTAGTTTACAAACCCATTTAAGTATGGAAT
GATTTATATGGGGTCAGGTGCTCCACAAAATAGACCTATGAGACCAAAAATGACCTAGGC
TATTTAGACGACAGCATGAAACTTCCACGTTAGTTCTCAGTCTATAAAGGCACTTACCGG
TCTCTGGTGTGGTATGACCAATAGAAACACCTTATAGTTTGCTTTGGACCTCATTTTGGA
AAAATAATCTGCCTTTCTAATTGTTCTGCATAGGTTAAAATGATAAATTTACATTCTTTG
AACCTATACCAGATTGTGGTGTCCGAGTGACCGGCACACTGTCTGACACACAGTCAGTGT
GCACGTATTTGTCTGAGTGAATGAGGAGACCTGAGAAACCGGTGACGTGGCACAGGGAAG
CCAGCTGGCCCAGGATTCCGTACATGGCCGCAAGCAGACTAACGCGTTGACGCTAATTTA
ATGTATTTTACCTCACACTAAGGTCATGCTTGATAAAGACGTTAAACTCAACTTGTAAAA
TGGTAGCCCAGTGCTATGCACAGAGTGGGTGCTCATTAGTGTTGAATGAACACATTTGTA
ATACTACATGTAATTCCATCTGACTGCTTTGTTAAATTTTCAGTTAGAACGTAGATACTG
TAAAGTCCACACACACATTAAATCTTGTTTTCCTGAAAGTATGGC

Protein Sequence

>1398 : length: 304
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA
RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD
EDFS